Medicines Control Authority of Zimbabwe

Public Clinical Trials Registry

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Page 1 of 2, showing 20 record(s) out of 22 total

Protocol No Public Title Scientific Title Date Submitted Date approved
CT183/2019 CT183/2019 MTN-042 CT183/2019 MTN-042: A Phase 3b, Randomized, Open Label, Safety Trial of Dapivirine Vaginal Ring and Oral TRUVADA Use in Pregnancy 12-11-2019 07:24 01-06-2020 View  
CT199/2020 AMC 102 A Randomized Phase II Trial of Concurrent Chemotherapy and Pelvic Radiation Therapy with or without Paclitaxel and Carboplatin in HIV-Positive Women with Locally Advanced Cervical Cancer (LACC) (Version 3.0 09JUL2019) 01-07-2020 13:32 03-04-2021 View  
CT176/2019 CT176, Therapeutic Approaches to Malnutrition Enteropathy (TAME) Therapeutic Approaches to Malnutrition Enteropathy: Phase II Trials of Four Novel Interventions in Children in Zambia and Zimbabwe 17-12-2019 11:29 09-02-2019 View  
CT219/2021 IMPOWER 022 A Phase 3, Randomized, Active-Controlled, Double-blind Clinical Study to Evaluate the Efficacy and Safety of Oral Islatravir Once-Monthly as Preexposure Prophylaxis in Cisgender Women at High Risk for HIV-1 Infection 30-06-2021 17:00 01-01-1970 View  
CT190/2020 Thermal Ablation Study Evaluation of the acceptability, safety and effectiveness of thermal ablation in the prevention of cervical neoplasia in Zimbabwe 27-03-2020 09:07 15-02-2021 View  
CT221/2021 A Phase I/II Study to Evaluate the Safety, Reactogenicity and Immunogenicity of RBD SARS-CoV-2 HBsAg VLP Vaccine in Healthy Adults 22-06-2021 20:10 10-11-2021 View  
CT220/2021 COMBI Cotrimoxazole for Mothers to improve birth weight in infants 09-07-2021 10:48 10-11-2021 View  
CT225/2021 R34 DPP Clinical Study-A crossover acceptability study assessing a DPP capsule for HIV and pregnancy prevention A randomized, crossover study to evaluate the acceptability of an over-encapsulated dual prevention pill (DPP capsule) containing pre-exposure prophylaxis (PrEP) and a combined oral contraceptive (COC) pill versus two separate tablets (PrEP and COC) among 14-09-2021 16:00 05-05-2022 View  
CT227/2021 HVTN 140/HPTN 101 A phase 1 dose-escalation clinical trial to evaluate the safety, tolerability, and pharmacokinetics of PGDM1400LS alone and in combination with VRC07-523LS and PGT121.414.LS in healthy, HIV-uninfected adult participants 01-10-2021 17:29 05-05-2022 View  
CT228/2021 BREATHER+ A randomized open-label 2-arm, 96-week trial evaluating the efficacy, safety and acceptability of short cycle (five days on, two days off) dolutegravir/tenofovir-based triple antiretroviral therapy (ART) compared to daily dolutegravir/tenofovir-based trip 01-11-2021 19:32 02-04-2022 View  
CT230/2022 ENGAGE A Phase II Acceptability Study of Oral emtricitabine/tenofovir alafenamide (F/TAF) vs emtricitabine/tenofovir disoproxil fumarate (F/TDF) for the Prevention of HIV Acquisition in Adolescent Girls and Young Women (AGYW) 23-02-2022 14:53 01-01-1970 View  
CT240/2022 Prof Prof 15-07-2022 11:55 09-08-2022 View  
CT232/2022 CCNO17 Clinical Evaluation of Daily Application of Nestorone® (NES) and Testosterone (T) Combination Gel for Male Contraception 27-02-2022 20:13 21-06-2022 View  
CT241/2022 IMAGINE-TBM -A5384 A Phase II, Randomized, Open-Label Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents with Tuberculous Meningitis: Improve 25-08-2022 16:12 12-12-2023 View  
CT243/2022 ZIMCoVVAR COVID 19 vaccine effectiveness and SARS CoV-2 variants in Zimbabwe:Test negative case control study, Genetic Sequencing and Serology 12-09-2022 14:12 20-10-2022 View  
CT258/2023 Annovera Study Pilot project to assess acceptability, uptake and continuation of Annovera® Contraceptive vaginal ring over 1 year (13 menstrual cycles) of use among adolescent girls and young women 16-24 years old seeking family planning services in two Mbare clinic 14-03-2023 15:01 01-08-2024 View  
CT246/2022 O-PrEP Optimizing PrEP regimens for pregnant women in sub-Saharan Africa 22-09-2022 09:55 12-12-2023 View  
CT247/2022 LATA Long-Acting Treatment in Adolescents (LATA): A randomised open-label 2-arm 96-week trial in virologically suppressed HIV-1-positive adolescents aged 12-19 years of age in Sub-Saharan Africa 14-10-2022 14:29 16-12-2022 View  
CT261/2023 The CATALYST Study Catalyzing access to new prevention products to stop HIV 23-06-2023 09:39 12-12-2023 View  
CT262/2023 An adaptive multi-arm trial to improve clinical outcomes among children recovering from complicated severe acute malnutrition (Co-SAM) 30-06-2023 18:59 01-02-2024 View